Progynova 1 mg is a hormone replacement therapy (HRT) tablet containing estradiol valerate, used to relieve symptoms of estrogen deficiency in peri- and postmenopausal women, such as hot flashes, vaginal dryness, and itching. It also helps prevent osteoporosis by replacing natural estrogen. The tablet is taken once daily at the same time for effectiveness. Common side effects include headaches, breast pain, and irregular vaginal bleeding.