A review of six randomized controlled trials in healthy older participants found no benefit from DHEA supplementation, at doses of 50 mg per day for two weeks to 12 months, on cognitive function in either men or women.173 In addition, a randomized placebo-controlled trial in 58 male and female Alzheimer disease patients found 50 mg of DHEA twice daily for six months did not improve cognition or reduce disease severity.1

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